Paediatric population. Monotherapy and combination with insulin • Glucophage can be used in children from 10 years of age and adolescents. • The usual starting dose is 500 mg or 850 mg metformin hydrochloride once daily, given during or after meals. The most common medication used in women with PCOS is the insulin-sensitizer metformin. Research is strongly showing that long-term use of metformin and at high doses (1.5mg or higher daily) can deplete levels of vitamin B12. USUAL DOSE: 500 mg PO once daily with the evening meal. In the geriatric adult, do not initiate therapy if 80 years old or older unless normal renal function is documented. Metformin side effects, use for diabetes treatment, dosage November 19 2018 by Ray Sahelian, M.D. Metformin is a drug used to treat type 2 diabetes mellitus. My gyno prescribed metformin 500 mg 2 x day for PCOS. He said it was an anti-diabetic but that it is also taken for PCOS. I have had a hard time managing my weight and he thought that it would help. At first I tried ovulation kits, but my periods were just too irregular. For my first child, my Dr put me on metformin. While on that, my periods became a little more regular at every 6 weeks. Metformin has been used to treat diabetes since the late 1950s. It is now on the World Health Organisation's List of Essential Medicines needed for a basic health care system. This eMedTV segment explains that the recommended starting dosage of metformin is 500 mg twice daily. The maximum dose of the drug will vary depending on several factors, such as age and other medications you are taking. Let me first say, I don’t hate Metformin for women with PCOS. For some women it really does help spur ovulation, control blood sugar and help with some weight management but….it’s not without its share of issues.And it’s definitely not the magic bullet for weight loss – although it’s usually presented that way. The usual starting dose is 15 mg pioglitazone/ 1000 mg metformin or 30 mg pioglitazone/ 1000 mg metformin once daily with an evening meal; gradually titrate after assessing adequacy of therapeutic response.